Mitotic Phosphorylation of Nucleoporins: Dismantling NPCs and Beyond
نویسندگان
چکیده
منابع مشابه
Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins
During interphase, the nuclear envelope (NE) serves as a selective barrier between cytosol and nucleoplasm. When vertebrate cells enter mitosis, the NE is dismantled in the process of nuclear envelope breakdown (NEBD). Disassembly of nuclear pore complexes (NPCs) is a key aspect of NEBD, required for NE permeabilization and formation of a cytoplasmic mitotic spindle. Here, we show that both CDK...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2011
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2011.02.013